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KMID : 1134820080370091136
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 9 p.1136 ~ p.1141
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Antiwrinkle Effects of Mugwort (Artemisia vulgaris) Extracts on UVB-Irradiated Hairless Mouse Skin
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Park Si-Hyang
Hong Yu-Mi
Choi Yeung-Joon
Choi Jin-Ho
Kim Byung-Kwan
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Abstract
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This study was to investigate antiwrinkle effect of mugwort (Artemisia vulgaris) methanol extract in hairless mouse skin induced by UVB-irradiation. Hairless mouse were topically treated with the basic lotion alone (control), ascorbic acid (AA-0.5%, AA-1.0%, AA-2.0%, and AA-5.0%) and mugwort extract (ME-0.5%, ME-1.0%, ME-2.0%, and ME-5.0%) dissolved in a basic lotion. After topical treatment of 30 minutes, the animals were irradiated with increasing doses of UVB radiation (60～100 mJ/㎠) for 4 weeks. In our experimental condition, skin thickness of hairless mouse was significantly decreased (12.5～21.4%) in all ME groups compared with control group. Ra value, that is surface roughness parameter induced by skin wrinkling, was significantly decreased (23.7～31.1%) in ME-1.0%, 2.0% and 5.0% group compared with control group. Furthermore, Rq, Rz and Rt value were significantly decreased to 11.2～21.2%, 19.8%～24.5%, and 14.2%～22.7%, respectively. Wrinkle formation of ascorbic acid treatment group as reference group was inhibited, but its effect was less than ME treatment. Matrix metalloproteinase-1 activity was significantly inhibited (19.7～22.6%) compared with control group and collagen content was significantly increased (about 10%) when compared with control group. These results indicate that ME could protect skin aging and wrinkle formation in hairless mouse from photo-irradiation.
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KEYWORD
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mugwort(Artemisia vulgaris), ascorbic acid, antiwrinkle, UVB, skin aging
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